Role of lipid mediators in the regulation of oxidative stress and inflammatory responses in dairy cattle
Periparturient dairy cows experience an increased incidence and severity of several
inflammatory-based diseases such as mastitis and metritis. Factors associated with the …
inflammatory-based diseases such as mastitis and metritis. Factors associated with the …
[HTML][HTML] Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology
Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats
M Temiz-Resitoglu, SP Kucukkavruk, DS Guden… - European Journal of …, 2017 - Elsevier
Mammalian target of rapamycin (mTOR), a serine/threonine kinase plays an important role
in various pathophysiological processes including cancer, metabolic diseases, and …
in various pathophysiological processes including cancer, metabolic diseases, and …
Inhibition of NLRP3 inflammasome prevents LPS-induced inflammatory hyperalgesia in mice: contribution of NF-κB, caspase-1/11, ASC, NOX, and NOS isoforms
A Dolunay, SP Senol, M Temiz-Resitoglu, DS Guden… - Inflammation, 2017 - Springer
The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular
signaling molecule that senses many environmental-and pathogen/host-derived factors, has …
signaling molecule that senses many environmental-and pathogen/host-derived factors, has …
[HTML][HTML] Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5, 14-HEDGE, a 20-HETE mimetic, against vasodilation …
We have previously demonstrated that a stable synthetic analog of 20-
hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5 (Z), 14 (Z)-dienoyl] glycine …
hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5 (Z), 14 (Z)-dienoyl] glycine …
Pharmacological inhibition of soluble epoxide hydrolase attenuates chronic experimental autoimmune encephalomyelitis by modulating inflammatory and anti …
M Biliktu, SP Senol, M Temiz-Resitoglu, DS Guden… - …, 2020 - Springer
We aimed to determine the effect of soluble epoxide hydrolase (sEH) inhibition on chronic
experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis …
experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis …
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase …
A Lakhkar, V Dhagia, SR Joshi… - American Journal …, 2016 - journals.physiology.org
20-Hydroxyeicosatetraeonic acid (20-HETE) produced by cytochrome P-450
monooxygenases in NADPH-dependent manner is proinflammatory, and it contributes to the …
monooxygenases in NADPH-dependent manner is proinflammatory, and it contributes to the …
Pharmacological inhibition of mammalian target of rapamycin attenuates deoxycorticosterone acetate salt–induced hypertension and related pathophysiology …
M Temiz-Resitoglu, DS Guden, SP Senol… - Journal of …, 2022 - journals.lww.com
The present study aimed to explore the contribution of mammalian target of rapamycin
(mTOR) in deoxycorticosterone acetate (DOCA) salt–induced hypertension and related …
(mTOR) in deoxycorticosterone acetate (DOCA) salt–induced hypertension and related …
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock
B Tunctan, SP Senol, M Temiz-Resitoglu… - Prostaglandins & Other …, 2019 - Elsevier
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Septic shock, the most common form of vasodilatory shock, is a subset of sepsis in …
infection. Septic shock, the most common form of vasodilatory shock, is a subset of sepsis in …
Protection by mTOR inhibition on zymosan-induced systemic inflammatory response and oxidative/nitrosative stress: contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α …
S Sahan-Firat, M Temiz-Resitoglu, DS Guden… - Inflammation, 2018 - Springer
Mammalian target of rapamycin (mTOR), a serine/threonine kinase regulate variety of
cellular functions including cell growth, differentiation, cell survival, metabolism, and stress …
cellular functions including cell growth, differentiation, cell survival, metabolism, and stress …