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Artificial nucleic acids of no bond crosslinkage type
T Imanishi, S Obika, K Miyashita - US Patent 7,427,672, 2008 - Google Patents
An oligonucleotide analogue useful for the antisense method, etc., having excellent enzyme
resistance, having potent selec tive binding a? inity for single-stranded RNA, and further …
resistance, having potent selec tive binding a? inity for single-stranded RNA, and further …
Oligonucleotide analogues
UGQMRVRMYYASKQ-KMPDEGCQSA-N Inosine Natural products O [C@ H] 1 [C@
H](O)[C@@ H](CO) O [C@@ H] 1N1C (N= CNC2= O)= C2N= C1 UGQMRVRMYYASKQ …
H](O)[C@@ H](CO) O [C@@ H] 1N1C (N= CNC2= O)= C2N= C1 UGQMRVRMYYASKQ …
Detection of nucleic acids
Q Nguyen, Y Ma, A Lin, S Levinson, C Lai - US Patent 9,273,349, 2016 - Google Patents
This invention provides compositions, methods, and systems for characterizing, resolving,
and quantitating single stranded and double stranded DNA and RNA in-situ. Paired sense …
and quantitating single stranded and double stranded DNA and RNA in-situ. Paired sense …
Nucleoside and oligonucleotide analogues
M Kaneko, K Morita, T Imanishi - US Patent 7,314,923, 2008 - Google Patents
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents Nucleoside …
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents Nucleoside …
Substituted nucleotide analogs
DB Smith, J Deval, N Dyatkina, L Beigelman… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
45818284&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
45818284&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Methods for treating hypercholesterolemia
SM Freier, RM Crooke, MJ Graham… - US Patent …, 2012 - Google Patents
2009-08-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Nucleoside and oligonucleotide analogues
M Kaneko, K Morita, T Imanishi - US Patent 7,335,765, 2008 - Google Patents
3,687,808 A 8, 1972 Merigan, Jr. et al. 4,689,320 A 8/1987 Kaji 4,806.463. A 2f1989
Goodchild et al. 5,004,810 A 4/1991 Draper 5,166,195 A 11/1992 Ecker 5, 194428 A 3/1993 …
Goodchild et al. 5,004,810 A 4/1991 Draper 5,166,195 A 11/1992 Ecker 5, 194428 A 3/1993 …
Oligomer-conjugate complexes and their use
TP Prakash, EE Swayze, WF Lima… - US Patent …, 2018 - Google Patents
2013-01-28 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
High potency siRNAS for reducing the expression of target genes
D Brown, L Ford, R Jarvis, V Pallotta… - US Patent App. 10 …, 2003 - Google Patents
(57) ABSTRACT Correspondence Address: FULBRIGHT & JAWORSKI LLP The present
invention provides improved methods of attenu 600 CONGRESSAVE. ating gene …
invention provides improved methods of attenu 600 CONGRESSAVE. ating gene …
Conjugated antisense compounds and their use
TP Prakash, PP Seth, EE Swayze - US Patent 9,127,276, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
51843959&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
51843959&utm_source= google_patent&utm_medium= platform_link&utm_campaign …