Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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CRISPR-based genome modification and regulation
F Chen, GD Davis - US Patent 10,731,181, 2020 - Google Patents
The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
CRISPR-based genome modification and regulation
F Chen, GD Davis - US Patent 10,745,716, 2020 - Google Patents
The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
Method of making a deletion in a target sequence in isolated primary cells using Cas9 and two guide RNAs
K Musunuru, CA Cowan, DJ Rossi - US Patent 9,822,370, 2017 - Google Patents
2014-11-24 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Genome engineering
Methods are provided for the use of Cas9 in genome engineering of stem cells. Methods
include introducing into the stem cell a first foreign nucleic acid encoding a guide RNA …
include introducing into the stem cell a first foreign nucleic acid encoding a guide RNA …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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Intracellular genomic transplant and methods of therapy
B Moriarity, B Webber, RS McIvor, M Choudhry… - US Patent …, 2019 - Google Patents
2017-01-19 Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA reassignment
REGENTS OF THE UNIVERSITY OF MINNESOTA ASSIGNMENT OF ASSIGNORS …
REGENTS OF THE UNIVERSITY OF MINNESOTA ASSIGNMENT OF ASSIGNORS …