Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is
critical for regulating homeostatic cellular function and communication, and disruptions of …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without …

Invasion causes cancer malignancy. We review recent data about cellular and molecular
mechanisms of invasion, focusing on cross-talk between the invaders and the host. Cancer …

Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Identification of the key regulatory molecules in metastasis is crucial for understanding tumor
dissemination and for the development of novel interventions. The recent identification of …