Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Hydrogels prepared from natural polymer have attracted extensive attention in biomedical
fields such as drug delivery, wound healing, and regenerative medicine due to their good …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

With an increasingly aging society, bone defects and fractures have become significant
threats to human health and quality of life. Currently, autologous and allogeneic bone grafts …

Hydrogels, exhibiting wide applications in soft robotics, tissue engineering, implantable
electronics, etc., often require sophisticately tailoring of the hydrogel mechanical properties …

Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

In spite of the considerable achievements in the field of regenerative medicine in the past
several decades, osteochondral defect regeneration remains a challenging issue among …

The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

Over the last few years, biopolymers have attracted great interest in tissue engineering and
regenerative medicine due to the great diversity of their chemical, mechanical, and physical …