Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential
risk factors enables clinicians to identify patients who are more likely to develop bipolar …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …

Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …

GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines—which …

Recent genetic studies reinforce the view that current approaches to the diagnosis and
classification of major psychiatric illness are inadequate. These findings challenge the …

Molecular genetic analysis offers opportunities to advance our understanding of the
nosological relationship between psychiatric diagnostic categories in general, and the mood …

Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …

There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …

Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …