LIM domain proteins in cell mechanobiology

CA Anderson, DR Kovar, ML Gardel… - …, 2021 - Wiley Online Library
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent
cells, largely through its regulation of adhesion and cortical tension. The LIM (L in‐11, I sl1 …

An overview of the cytoskeleton-associated role of PDLIM5

X Huang, R Qu, J Ouyang, S Zhong, J Dai - Frontiers in Physiology, 2020 - frontiersin.org
Regenerative medicine represented by stem cell technology has become one of the pillar
medical technologies for human disease treatment. Cytoskeleton plays important roles in …

Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents

L Antounians, VD Catania, L Montalva, BD Liu… - Science Translational …, 2021 - science.org
Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …

Plasma sRAGE acts as a genetically regulated causal intermediate in sepsis-associated acute respiratory distress syndrome

TK Jones, R Feng, VE Kerchberger… - American journal of …, 2020 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers.
Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) …

PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells

Y Shi, X Wang, Z Xu, Y He, C Guo, L He, C Huan… - Journal of Biological …, 2020 - ASBMB
Transforming growth factor β (TGFβ) signaling plays an important role in regulating tumor
malignancy, including in non–small cell lung cancer (NSCLC). The major biological …

Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study

JC Nwanaji-Enwerem, E Colicino… - Environmental …, 2016 - academic.oup.com
Background: Ambient particles have been shown to exacerbate measures of biological
aging; yet, no studies have examined their relationships with DNA methylation age (DNAm …

PDZ and LIM domain-encoding genes: their role in cancer development

X Jiang, Z Xu, S Jiang, H Wang, M **ao, Y Shi, K Wang - Cancers, 2023 - mdpi.com
Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …

Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension

J Dai, Q Zhou, H Tang, T Chen, J Li, P Raychaudhuri… - Cellular signalling, 2018 - Elsevier
Abstract Rationale Forkhead box M1 (FoxM1) is a transcription factor that promotes cell
proliferation by regulating a broad spectrum of genes that participate in cell cycle regulation …

PDLIM5 affects chicken skeletal muscle satellite cell proliferation and differentiation via the p38-MAPK pathway

H He, H Yin, X Yu, Y Zhang, M Ma, D Li, Q Zhu - Animals, 2021 - mdpi.com
Simple Summary PDZ and LIM domain 5 (PDLIM5) can increase C2C12 cell differentiation;
however, the role of PDLIM5 in chicken skeletal muscle satellite cells (SMSCs) is unclear. In …

Long Non-coding RNA AGAP2-AS1 Silencing Inhibits PDLIM5 Expression Impeding Prostate Cancer Progression via Up-Regulation of MicroRNA-195-5p

P **e, M Liu, F Chen, S Wu, T Shao, W Wang… - Frontiers in …, 2020 - frontiersin.org
Prostate cancer remains a significant cause of cancer-related deaths in male population.
More recently, accumulating evidence continues to implicate long non-coding RNAs …