Metabolomics-based engineering for biofuel and bio-based chemical production in microalgae and cyanobacteria: A review

Y Kato, K Inabe, R Hidese, A Kondo… - Bioresource Technology, 2022 - Elsevier
Metabolomics, an essential tool in modern synthetic biology based on the design-build-test-
learn platform, is useful for obtaining a detailed understanding of cellular metabolic …

[HTML][HTML] Design and construction of microbial cell factories based on systems biology

W Yan, Z Cao, M Ding, Y Yuan - Synthetic and systems biotechnology, 2023 - Elsevier
Environmental sustainability is an increasingly important issue in industry. As an
environmentally friendly and sustainable way, constructing microbial cell factories to …

Metabolomics-driven approach to solving a CoA imbalance for improved 1-butanol production in Escherichia coli

T Ohtake, S Pontrelli, WA Laviña, JC Liao, SP Putri… - Metabolic …, 2017 - Elsevier
High titer 1-butanol production in Escherichia coli has previously been achieved by
overexpression of a modified clostridial 1-butanol production pathway and subsequent …

Metabolomics of astaxanthin biosynthesis and corresponding regulation strategies in Phaffia rhodozyma

H Yang, L Yang, X Du, N He, Z Jiang, Y Zhu, L Li, H Ni… - Yeast, 2023 - Wiley Online Library
Astaxanthin is a valuable carotenoid and is used as antioxidant and health care. Phaffia
rhodozyma is a potential strain for the biosynthesis of astaxanthin. The unclear metabolic …

Metabolic engineering tools in model cyanobacteria

AL Carroll, AE Case, A Zhang, S Atsumi - Metabolic engineering, 2018 - Elsevier
Develo** sustainable routes for producing chemicals and fuels is one of the most
important challenges in metabolic engineering. Photoautotrophic hosts are particularly …

Genetic engineering of non-native hosts for 1-butanol production and its challenges: a review

S Nawab, N Wang, X Ma, YX Huo - Microbial cell factories, 2020 - Springer
Background Owing to the increase in energy consumption, fossil fuel resources are
gradually depleting which has led to the growing environmental concerns; therefore …

Iterative cycle of widely targeted metabolic profiling for the improvement of 1-butanol titer and productivity in Synechococcus elongatus

AM Fathima, D Chuang, WA Laviña, J Liao… - Biotechnology for …, 2018 - Springer
Background Metabolomics is the comprehensive study of metabolites that can demonstrate
the downstream effects of gene and protein regulation, arguably representing the closest …

Insights into isoprene production using the cyanobacterium Synechocystis sp. PCC 6803

N Pade, S Erdmann, H Enke, F Dethloff… - Biotechnology for …, 2016 - Springer
Background Cyanobacteria are phototrophic prokaryotes that convert inorganic carbon as
CO 2 into organic compounds at the expense of light energy. They need only inorganic …

[HTML][HTML] Thermodynamic analysis of computed pathways integrated into the metabolic networks of E. coli and Synechocystis reveals contrasting expansion potential

J Asplund-Samuelsson, M Janasch, EP Hudson - Metabolic engineering, 2018 - Elsevier
Introducing biosynthetic pathways into an organism is both reliant on and challenged by
endogenous biochemistry. Here we compared the expansion potential of the metabolic …

Unlocking the photobiological conversion of CO 2 to (R)-3-hydroxybutyrate in cyanobacteria

B Wang, W **ong, J Yu, PC Maness, DR Meldrum - Green Chemistry, 2018 - pubs.rsc.org
Escalating concerns about CO2 emission from fossil fuel utilization and environmental
pollution from fossil-derived plastic waste call for the sustainable production and utilization …