Cancer continues to be a major global health challenge, accounting for 10 million deaths
annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 …

Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …

The presence of noncanonical open reading frames within lncRNAs (long non-coding
RNAs) suggests their potential for translation, yielding various functional peptides or …

Emerging evidence suggests that cryptic translation beyond the annotated translatome
produces proteins with developmental or physiological functions. However, functions of …

Studies have revealed dozens of functional peptides in putative 'noncoding'regions and
raised the question of how many proteins are encoded by noncanonical open reading …

The growing information currently available on the central role of non-coding RNAs
(ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic …

The context of long noncoding RNAs (lncRNAs) contains many unannotated open reading
frames (ORFs). These ORFs potentially encode novel proteins or peptides with crucial roles …

Evolutionary innovations can be driven by changes in the rates of RNA translation and the
emergence of new genes and small open reading frames (sORFs). In this study, we …

Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as
noncoding might generate microproteins with oncogenic functions. However, the importance …