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The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
NLRP3 inflammasome in cancer and metabolic diseases
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
Pattern recognition receptors in health and diseases
D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
Advances in mechanism and regulation of PANoptosis: prospects in disease treatment
PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …
[HTML][HTML] Cell death regulation: a new way for natural products to treat osteoporosis
Z Li, D Li, R Chen, S Gao, Z Xu, N Li - Pharmacological research, 2023 - Elsevier
Osteoporosis is a common metabolic bone disease that results from the imbalance of
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …
Role of the inflammasome in liver disease
M de Carvalho Ribeiro, G Szabo - Annual Review of Pathology …, 2022 - annualreviews.org
The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
Pathway paradigms revealed from the genetics of inflammatory bowel disease
DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …
amplified by the confluence of multiple genetic and environmental variables that perturb the …
[HTML][HTML] From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways
Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …
Mitochondria-derived cell-to-cell communication
In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …
outside the cells from which they originate. As a result, they are capable of acting on non …
Caspase-1 initiates apoptosis in the absence of gasdermin D
K Tsuchiya, S Nakajima, S Hosojima… - Nature …, 2019 - nature.com
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis,
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …