Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Mechanisms linking the human gut microbiome to prophylactic and treatment strategies for COVID-19

GE Walton, GR Gibson, KA Hunter - British Journal of Nutrition, 2021 - cambridge.org
The recent COVID-19 pandemic has altered the face of biology, social interaction and public
health worldwide. It has had a destructive effect upon millions of people and is approaching …

The core human microbiome: does it exist and how can we find it? A critical review of the concept

I Sharon, NM Quijada, E Pasolli, M Fabbrini, F Vitali… - Nutrients, 2022 - mdpi.com
The core microbiome, which refers to a set of consistent microbial features across
populations, is of major interest in microbiome research and has been addressed by …

Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68

Y Wang, SA Tibbetts, LT Krug - Annual review of virology, 2021 - annualreviews.org
Gammaherpesviruses are an important class of oncogenic pathogens that are exquisitely
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …

Fibrinolytic serine proteases, therapeutic serpins and inflammation: fire dancers and firestorms

JR Yaron, L Zhang, Q Guo, SE Haydel… - Frontiers in …, 2021 - frontiersin.org
The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

Intestinal Microbiota—A Promising Target for Antiviral Therapy?

M Yang, Y Yang, Q He, P Zhu, M Liu, J Xu… - Frontiers in …, 2021 - frontiersin.org
The intestinal microbiota is thought to be an important biological barrier against enteric
pathogens. Its depletion, however, also has curative effects against some viral infections …

Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins

K Varkoly, R Beladi, M Hamada, G McFadden, J Irving… - Biomolecules, 2023 - mdpi.com
Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …

Gut microbiome and anti-viral immunity in COVID-19

V Rossini, V Tolosa-Enguis… - Critical reviews in …, 2024 - Taylor & Francis
SARS-CoV-2 mainly affects the respiratory system, but the gastrointestinal tract is also a
target. Prolonged gut disorders, in COVID-19 patients, were correlated with decreased …

The interplay between the host microbiome and pathogenic viral infections

R González, SF Elena - MBio, 2021 - Am Soc Microbiol
The microorganisms associated with an organism, the microbiome, have a strong and wide
impact in their host biology. In particular, the microbiome modulates both the host defense …

Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines

K Chrzastek, J Leng, MK Zakaria, D Bialy… - Animal microbiome, 2021 - Springer
Background A commensal microbiota regulates and is in turn regulated by viruses during
host infection which can influence virus infectivity. In this study, analysis of colon microbiota …