How can nanotechnology help to combat COVID-19? Opportunities and urgent need
Incidents of viral outbreaks have increased at an alarming rate over the past decades. The
most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread …
most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread …
Immune cells as tumor drug delivery vehicles
F Combes, E Meyer, NN Sanders - Journal of Controlled Release, 2020 - Elsevier
This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
Although the first nanomedicine was clinically approved more than two decades ago,
nanoparticles'(NP) in vivo behavior is complex and the immune system's role in their …
nanoparticles'(NP) in vivo behavior is complex and the immune system's role in their …
[HTML][HTML] Controlled spatial characteristics of ligands on nanoparticles: determinant of cellular functions
Interactions of various ligands and receptors have been extensively investigated because
they regulate a series of signal transduction leading to various functional cellular outcomes …
they regulate a series of signal transduction leading to various functional cellular outcomes …
[HTML][HTML] Perspectives on nano-nutraceuticals to manage pre and post COVID-19 infections
Optimized therapeutic bio-compounds supported by bio-acceptable nanosystems (ie,
precise nanomedicine) have ability to promote health via maintaining body structure, organ …
precise nanomedicine) have ability to promote health via maintaining body structure, organ …
Leveraging the modularity of biomaterial carriers to tune immune responses
SJ Tsai, SK Black, CM Jewell - Advanced functional materials, 2020 - Wiley Online Library
Biomaterial carriers offer modular features to control the delivery and presentation of
vaccines and immunotherapies. This tunability is a distinct capability of biomaterials …
vaccines and immunotherapies. This tunability is a distinct capability of biomaterials …
Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis
Sepsis is characterized by a dysregulated immune response and is very difficult to treat. In
the cecal ligation and puncture (CLP) mouse model, we show that nanomedicines can …
the cecal ligation and puncture (CLP) mouse model, we show that nanomedicines can …
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics
Z Wang, P Sun, J Su, N Zhang, H Gu, Y Zhao - Journal of Controlled …, 2021 - Elsevier
Ligands, mostly binding to proteins to form complexes and catalyze chemical reactions, can
serve as drug and probe molecules, as well as sensing elements. DNA nanotechnology can …
serve as drug and probe molecules, as well as sensing elements. DNA nanotechnology can …
A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system
Highlights•Cancer nanomedicine traditionally aims to target chemotherapeutic drugs to
tumors.•Chemotherapy targeting does not overcome the treatment-response-relapse vicious …
tumors.•Chemotherapy targeting does not overcome the treatment-response-relapse vicious …