How can nanotechnology help to combat COVID-19? Opportunities and urgent need

EVR Campos, AES Pereira, JL De Oliveira… - Journal of …, 2020 - Springer
Incidents of viral outbreaks have increased at an alarming rate over the past decades. The
most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread …

Immune cells as tumor drug delivery vehicles

F Combes, E Meyer, NN Sanders - Journal of Controlled Release, 2020 - Elsevier
This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

J Deprez, R Verbeke, S Meulewaeter, I Aernout… - Nature …, 2023 - nature.com
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …

Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking

AM Sofias, YC Toner, AE Meerwaldt, MMT van Leent… - ACS …, 2020 - ACS Publications
Although the first nanomedicine was clinically approved more than two decades ago,
nanoparticles'(NP) in vivo behavior is complex and the immune system's role in their …

[HTML][HTML] Controlled spatial characteristics of ligands on nanoparticles: determinant of cellular functions

Y Choi, BK Cho, SH Seok, C Kim, JH Ryu… - Journal of Controlled …, 2023 - Elsevier
Interactions of various ligands and receptors have been extensively investigated because
they regulate a series of signal transduction leading to various functional cellular outcomes …

[HTML][HTML] Perspectives on nano-nutraceuticals to manage pre and post COVID-19 infections

AK Dubey, SK Chaudhry, HB Singh, VK Gupta… - Biotechnology …, 2022 - Elsevier
Optimized therapeutic bio-compounds supported by bio-acceptable nanosystems (ie,
precise nanomedicine) have ability to promote health via maintaining body structure, organ …

Leveraging the modularity of biomaterial carriers to tune immune responses

SJ Tsai, SK Black, CM Jewell - Advanced functional materials, 2020 - Wiley Online Library
Biomaterial carriers offer modular features to control the delivery and presentation of
vaccines and immunotherapies. This tunability is a distinct capability of biomaterials …

Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis

R Mathur, S Elsafy, AT Press, J Brück, M Hornef… - ACS …, 2024 - ACS Publications
Sepsis is characterized by a dysregulated immune response and is very difficult to treat. In
the cecal ligation and puncture (CLP) mouse model, we show that nanomedicines can …

DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics

Z Wang, P Sun, J Su, N Zhang, H Gu, Y Zhao - Journal of Controlled …, 2021 - Elsevier
Ligands, mostly binding to proteins to form complexes and catalyze chemical reactions, can
serve as drug and probe molecules, as well as sensing elements. DNA nanotechnology can …

A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system

AM Sofias, F Combes, S Koschmieder, G Storm… - Drug discovery today, 2021 - Elsevier
Highlights•Cancer nanomedicine traditionally aims to target chemotherapeutic drugs to
tumors.•Chemotherapy targeting does not overcome the treatment-response-relapse vicious …