Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

Melanomas comprise multiple biologically distinct categories, which differ in cell of origin,
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

Epithelial–mesenchymal transition (EMT) contributes to tumor invasion and metastasis in
many cancers and correlates highly with the acquisition of cancer stem cell (CSC) …

Cutaneous melanoma (CM) is one of the most rapidly growing cancers worldwide, with a
consistent increase in incidence among white populations over the past four decades …

Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of develo** melanoma …

Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly
involve the use of next-generation sequencing and comparative genomic hybridization …

Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …