Epigenetics-targeted drugs: Current paradigms and future challenges

W Dai, X Qiao, Y Fang, R Guo, P Bai, S Liu… - … and Targeted Therapy, 2024 - nature.com
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

AA Bhat, M Afzal, E Moglad, R Thapa, H Ali… - Clinical and …, 2024 - Springer
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular
processes, including cancer progression and stress response. Recent studies have …

[HTML][HTML] Oxidative stress and senescence in aging kidneys: the protective role of SIRT1

WH Almalki, SS Almujri - EXCLI journal, 2024 - pmc.ncbi.nlm.nih.gov
Aging leads to a gradual decline in kidney function, making the kidneys increasingly
vulnerable to various diseases. Oxidative stress, together with cellular senescence, has …

Enhancements in Parkinson's Disease Management: Leveraging Levodopa Optimization and Surgical Breakthroughs

R Sharma, A Kour, HK Dewangan - Current Drug Targets, 2025 - benthamdirect.com
Parkinson's disease (PD) is a complex neurological condition caused due to inheritance,
environment, and behavior among various other parameters. The onset, diagnosis, course …

Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer's disease

M Singh, H Ali, SR Jyothi, I Kaur, S Kumar, N Sharma… - Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
abnormal accumulation of tau proteins and amyloid-β, leading to neuronal death and …

[HTML][HTML] Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance

G Lazzeri, P Lenzi, CL Busceti… - International Journal of …, 2024 - mdpi.com
Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative
disorders such as Parkinson's disease, and it is characterized by membrane organelles …

Formulation and optimization of fisetin nanoemulsion for the treatment of Alzheimer's disease in rats: Pharmacokinetic and pharmacodynamic assessment

S Vishwas, R Kumar, A Awasthi, L Corrie… - Journal of Drug Delivery …, 2024 - Elsevier
Fiestin (FS) is a polyphenolic flavonoid that possesses various neuroprotective effects by
attenuating the levels of AChE enzyme, accumulated amyloid β, free radicals and …

Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

ASA Altamimi, N Ghaboura, AK Balaraman… - … -Research and Practice, 2024 - Elsevier
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a
novel form of regulated cell death known as disulfidptosis, characterized by accumulating …

Therapeutic Approaches to Microglial Dysfunction in Alzheimer's Disease: Enhancing Phagocytosis and Metabolic Regulation

WH Almalki, SS Almujri - Pathology-Research and Practice, 2024 - Elsevier
Microglia are essential in neurogenesis, synaptic pruning, and homeostasis. Nevertheless,
aging, and cellular senescence may modify their role, causing them to shift from being …

The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology

AA Bhat, ASA Altamimi, A Goyal, K Goyal, I Kaur… - International …, 2025 - Elsevier
CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for
hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless …