Mitochondrial diseases are a diverse family of genetic disorders caused by mutations
affecting mitochondrial proteins encoded in either the nuclear or the mitochondrial genome …

The cellular slime mold Dictyostelium discoideum has become an increasingly useful model
for the study of mitochondrial biology and disease. Dictyostelium is an amoebazoan, a sister …

Autophagy is a degradative recycling process central to the maintenance of homeostasis in
all eukaryotes. By ensuring the degradation of damaged mitochondria, it plays a key role in …

The complex cytopathology of mitochondrial diseases is usually attributed to insufficient
ATP. AMP-activated protein kinase (AMPK) is a highly sensitive cellular energy sensor that …

The feasibility of using random insertional mutagenesis to isolate mutants of the flavinogenic
yeast Candida famata was explored. Mutagenesis was performed by transformation of the …

The neuronal ceroid lipofuscinoses comprise a group of neurodegenerative disorders with
similar clinical manifestations whose precise mechanisms of disease are presently …

The single Dictyostelium chaperonin 60 gene, hspA, was cloned, sequenced and
characterized. Sequence comparisons and a three-dimensional model for the structure of …

Restriction enzyme-mediated integration (REMI) has been used to study a number of
cellular and developmental processes in Dictyostelium discoideum. In this paper we review …

The inactivation of proteins in cells is inevitable to study their physiological role in various
cellular processes. In contrast to strategies to alter the amount of active proteins in cells, only …

Actin filaments and microtubules are two major cytoskeletal systems involved in wide
cellular processes, and the organizations of their filamentous networks are regulated by a …