Genetic impacts on DNA methylation: research findings and future perspectives
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Air pollution and DNA methylation: effects of exposure in humans
Air pollution exposure is estimated to contribute to approximately seven million early deaths
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …
Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrou** has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …
understand mechanisms underpinning gene regulation and disease. In the present study …
ChAMP: updated methylation analysis pipeline for Illumina BeadChips
Abstract Summary The Illumina Infinium HumanMethylationEPIC BeadChip is the new
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
Trophoblast organoids as a model for maternal–fetal interactions during human placentation
The placenta is the extraembryonic organ that supports the fetus during intrauterine life.
Although placental dysfunction results in major disorders of pregnancy with immediate and …
Although placental dysfunction results in major disorders of pregnancy with immediate and …
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis
Abstract The AURORA US Metastasis Project was established with the goal to identify
molecular features associated with metastasis. We assayed 55 females with metastatic …
molecular features associated with metastasis. We assayed 55 females with metastatic …