Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

LA Silva, TS Dermody - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …

Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy

SD Thiberville, N Moyen, L Dupuis-Maguiraga… - Antiviral research, 2013 - Elsevier
Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …

Arthritogenic alphaviruses—an overview

A Suhrbier, MC Jaffar-Bandjee, P Gasque - Nature Reviews …, 2012 - nature.com
Mosquito-transmitted alphaviruses causing human rheumatic disease are globally
distributed and include chikungunya virus, Ross River virus, Barmah Forest virus, Sindbis …

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus

P Pal, KA Dowd, JD Brien, MA Edeling… - PLoS …, 2013 - journals.plos.org
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global
epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the …

A molecular understanding of alphavirus entry and antibody protection

AS Kim, MS Diamond - Nature Reviews Microbiology, 2023 - nature.com
Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

YW Kam, FM Lum, TH Teo, WWL Lee… - EMBO molecular …, 2012 - embopress.org
Chikungunya virus (CHIKV) and related arboviruses have been responsible for large
epidemic outbreaks with serious economic and social impact. The immune mechanisms …

Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus

SA Smith, LA Silva, JM Fox, AI Flyak, N Kose… - Cell host & …, 2015 - cell.com
Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus that causes acute febrile
infection associated with polyarthralgia in humans. Mechanisms of protective immunity …

A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus

S Brandler, C Ruffié, C Combredet, JB Brault… - Vaccine, 2013 - Elsevier
Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, recently reemerged in the
Indian Ocean, India and Southeast Asia, causing millions of cases of severe polyarthralgia …

Towards antivirals against chikungunya virus

R Abdelnabi, J Neyts, L Delang - Antiviral research, 2015 - Elsevier
Chikungunya virus (CHIKV) has re-emerged in recent decades, causing major outbreaks of
chikungunya fever in many parts of Africa and Asia, and since the end of 2013 also in …

Chikungunya and arthritis: An overview

R Kumar, S Ahmed, HA Parray, S Das - Travel medicine and infectious …, 2021 - Elsevier
Chikungunya is caused by CHIKV (chikungunya virus), an emerging and re-emerging
arthropod-vectored viral infection that causes a febrile disease with primarily long term …