The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

The accumulation of misfolded protein aggregates is a common feature of numerous
neurodegenerative disorders including Alzheimer disease (AD). Here, we examined the …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …

Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of
life. If improved therapeutics are not developed, the prevalence of AD will drastically …

Gene expression profiling of human substantia nigra pars compacta (SNpc) from
Parkinson's disease (PD) patients, was examined employing high density microarrays. We …

Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …

Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …