Many methods allow us to extract biological activities from omics data using information from
prior knowledge resources, reducing the dimensionality for increased statistical power and …

Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …

Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast
growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However …

Despite producing a panoply of potential cancer-specific targets, the proteogenomic
characterization of human tumors has yet to demonstrate value for precision cancer …

The continued growth of data from biological screening and medicinal chemistry provides
opportunities for data-driven experimental design and decision making in early-phase drug …

Achieving sufficient coverage of regulatory phosphorylation sites by mass spectrometry (MS)-
based phosphoproteomics for signaling pathway reconstitution is challenging, especially …

The metabolic enzyme branched-chain amino acid transaminase 1 (BCAT1) drives cell
proliferation in aggressive cancers such as glioblastoma. Here, we show that BCAT1 …

Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of chronic liver
disease with few therapeutic options. To narrow the translational gap in the development of …

Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic
control by protein phosphorylation. Here, we establish microglia as a new cellular …

Transforming growth factor–β (TGF-β) signaling regulates various aspects of cell growth and
differentiation and is often dysregulated in human cancers. We combined genetic …