The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …

Neuronal membrane excitability must be resilient to perturbations that can take place over
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …

Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of
underlying causes. However, determining which model parameters agree with complex and …

A hallmark of adaptation in humans and other animals is our ability to control how we think
and behave across different settings. Research has characterized the various forms …

Small rhythmic circuits, such as those found in invertebrates, have provided fundamental
insights into how circuit dynamics depend on individual neuronal and synaptic properties …

Biological neurons show significant cell-to-cell variability but have the striking ability to
maintain their key firing properties in the face of unpredictable perturbations and stochastic …

In 1996, we published a review article (Marder E, Calabrese RL. Physiol Rev 76: 687–717,
1996) describing the state of knowledge about the structure and function of the central …

Neurons and neuronal circuits must maintain their function throughout the life of the
organism despite changing environments. Previous theoretical and experimental work …

Neural circuits can produce similar activity patterns from vastly different combinations of
channel and synaptic conductances. These conductances are tuned for specific activity …

Years of basic neuroscience on the modulation of the small circuits found in the crustacean
stomatogastric ganglion have led us to study the effects of temperature on the motor patterns …