Immortalized cell lines are widely used in vitro tools in oncology and hematology research.
While these cell lines represent artificial systems and may accumulate genetic aberrations …

WHEN IT WAS first identified, platelet glycoprotein GPIV was shown to have a remarkable
resistance to protease digestion. 1., 2. It was subsequently shown to be relatively increased …

The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia
(CML), has been implicated as the cause of this disease. A compound, designed to inhibit …

THE development of blood cells including expansion of megakaryocyte progenitor cells
requires the interplay of marrow stromal cells and polypeptide cytokines1–10. Recently …

The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem
cell factor (SCF) to c-kit receptor (c-kitR) is known to activate c-kitR tyrosine kinase, thereby …

Random phage display peptide libraries and affinity selective methods were used to isolate
small peptides that bind to and activate the receptor for the cytokine erythropoietin (EPO). In …

MEGAKARYOCYTOPOIESIS is the cellular developmental process that leads to platelet
production. At least two humoral growth factors may be necessary for megakaryocyte …

CGP 57148 is a compound of the 2-phenylaminopyrimidine class that selectively inhibits the
tyrosine kinase activity of the ABL and the platelet-derived growth factor receptor (PDGFR) …

Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), in addition to being a growth
factor for granulocytes and macrophages, is an activator of cells of the monocyte …

How multiple chemoattractants cooperate in directing the migration of hematopoietic
progenitor cells (HPC) for homing and peripheral blood mobilization has not yet been …