Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Changes in gene expression in brain reward regions are thought to contribute to the
pathogenesis and persistence of drug addiction. Recent studies have begun to focus on the …

Tolerance represents a critical component of addiction. The large-conductance calcium-and
voltage-activated potassium channel (BK) is a well-established alcohol target, and an …

Addiction is a debilitating psychiatric disorder, with a complex aetiology involving the
interaction of inherited predispositions and environmental factors. Emerging evidence …

Background Some of the most frequent deficits seen in children with fetal alcohol spectrum
disorders (FASD) and in animal models of FASD are spatial memory impairments and …

This review is dedicated to the memory of our dear friend and colleague Professor Werner
Kalow (1916–2008) A brief history of human genetics and genomics is provided, comparing …

Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for
reward and addiction research. Modeling drug abuse-related behavior in both adult and …

Background: Rapid tolerance to the anxiolytic effects of ethanol appears to be an important
factor in the development of alcoholism. Here, we investigated the involvement of …

Introduction: Epigenetics is the study of reversible modifications to chromatin and their
extensive and profound effects on gene regulation. To date, the role of epigenetics in …

Background: Increased ethanol intake, a major predictor for the development of alcohol use
disorders, is facilitated by the development of tolerance to both the aversive and pleasurable …