The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …

Cationic polymers have recently attracted considerable interest as research breakthroughs
for various industrial and biomedical applications. They are particularly interesting due to …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The advent of human induced pluripotent stem cells (iPSCs) presents unprecedented
opportunities to model human diseases. Differentiated cells derived from iPSCs in two …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …