The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

Once known exclusively for their role in nutrients absorption, primary bile acids,
chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …