Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …

Covalent inhibitors have been a rapidly growing field in drug discovery due to their
therapeutic potential and unique advantages in cancer therapy. As opposed to noncovalent …

The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System
encompasses 3 enzymes that form Angiotensin-(1-7)[Ang-(1-7)] directly from Ang II: ACE2 …

Purpose The fibroblast activation protein (FAP) is an emerging target for molecular imaging
and therapy in cancer. OncoFAP is a novel small organic ligand for FAP with very high …

Fibroblast activation protein-α (FAP) is a serine protease that can provide target specificity to
therapeutic agents because in adults its expression is restricted to pathologic sites, including …

Bioactive peptides and carbohydrates are sourced from a myriad of plant, animal and
insects and have huge potential for use as food ingredients and pharmaceuticals. However …

The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating
hypertension by controlling vasoconstriction and intravascular fluid volume. RAAS itself is …

Many enzymes contain tunnels and gates that are essential to their function. Gates
reversibly switch between open and closed conformations and thereby control the traffic of …

Although drug development typically focuses on binding thermodynamics, recent studies
suggest that kinetic properties can strongly impact a drug candidate's efficacy. Robust …

A series of novel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise
selective, potent modulators of the protein–protein interaction (PPI)-mediated functions of …