Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

The field of epitranscriptomics examines the recently deciphered form of gene expression
regulation that is mediated by type-and site-specific RNA modifications. Similarly to the role …

Summary N6-methyladenosine (m 6 A) is the most abundant modification on mRNA and is
implicated in critical roles in development, physiology, and disease. A major limitation has …

Abstract N 6-methyladenosine (m6A) RNA methylation contributes to the cancer stem cell
(CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown …

Abstract N 6-methyladenosine (m6A) is the most prevalent modification of messenger RNA
in mammals. To interrogate its functions and dynamics, there is a critical need to quantify …

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Various methyltransferases and demethylases catalyse methylation and demethylation of N
6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine (m6Am) but precise …

Abstract N 6-methyladenosine (m 6 A) is the most common post-transcriptional RNA
modification throughout the transcriptome, affecting fundamental aspects of RNA …

Alternative splicing of pre-mRNA increases genetic diversity, and recent studies estimate
that most human multiexon genes are alternatively spliced. If this process is not highly …