Aberrant pre-mRNA processing in cancer
J Biswas, L Boussi, E Stein… - Journal of Experimental …, 2024 - rupress.org
Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …
all cancer types. In this review, we described the current state of understanding of how RNA …
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
Decoding biology with massively parallel reporter assays and machine learning
Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of
sequence variation on gene expression. Reading out molecular phenotypes with …
sequence variation on gene expression. Reading out molecular phenotypes with …
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer
G Pagani, P Gandellini - Cancer Gene Therapy, 2024 - nature.com
The role of alternative polyadenylation of mRNA in sustaining aggressive features of tumors
is quite well established, as it is responsible for the 3'UTR shortening of oncogenes and …
is quite well established, as it is responsible for the 3'UTR shortening of oncogenes and …
Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3′ ends
L Liu, JL Manley - RNA, 2024 - rnajournal.cshlp.org
The cleavage and polyadenylation specificity factor (CPSF) complex plays a central role in
the formation of mRNA 3′ ends, being responsible for the recognition of the poly (A) signal …
the formation of mRNA 3′ ends, being responsible for the recognition of the poly (A) signal …
CPSF3 as a Therapeutic Target in Pancreatic Cancer
AAA Alahmari - 2024 - search.proquest.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective
treatment options, potentiating the importance of uncovering novel drug targets. Large-scale …
treatment options, potentiating the importance of uncovering novel drug targets. Large-scale …
RBBP6 anchors pre-mRNA 3′ end processing to nuclear speckles for efficient gene expression
Pre-mRNA 3′ processing is an integral step in mRNA biogenesis. However, where this
process occurs in the nucleus remains unknown. Here, we demonstrate that nuclear …
process occurs in the nucleus remains unknown. Here, we demonstrate that nuclear …