Programmed cell death: the pathways to severe COVID-19?
Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …
[HTML][HTML] Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19?
K Saleki, P Alijanizadeh, A Azadmehr - Biomedicine & Pharmacotherapy, 2023 - Elsevier
A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
COVID-19 displays diverse disease severities and symptoms including acute systemic
inflammation and hypercytokinemia, with subsequent dysregulation of immune cells …
inflammation and hypercytokinemia, with subsequent dysregulation of immune cells …
The pathogenesis of organ fibrosis: Focus on necroptosis
M Hao, X Han, Z Yao, H Zhang, M Zhao… - British Journal of …, 2023 - Wiley Online Library
Fibrosis is a common process of tissue repair response to multiple injuries in all chronic
progressive diseases, which features with excessive deposition of extracellular matrix …
progressive diseases, which features with excessive deposition of extracellular matrix …
Differential activation of programmed cell death in patients with severe SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe lower
airway disease and death in a subset of patients. Knowledge on the relative contribution of …
airway disease and death in a subset of patients. Knowledge on the relative contribution of …
Targeting Neutrophil β2-Integrins: A Review of Relevant Resources, Tools, and Methods
Neutrophils are important innate immune cells that respond during inflammation and
infection. These migratory cells utilize β2-integrin cell surface receptors to move out of the …
infection. These migratory cells utilize β2-integrin cell surface receptors to move out of the …
Serum soluble Fas ligand is a severity and mortality prognostic marker for COVID-19 patients
Finding cytokine storm initiator factors associated with uncontrolled inflammatory immune
response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas …
response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas …
RIP kinases and necroptosis in aging and aging-related diseases
Y Yang, X Li, T Zhang, D Xu - Life Medicine, 2022 - academic.oup.com
Aging is a natural process that is characterized by chronic, low-grade inflammation, which
represents the primary risk factor in the pathogenesis of a variety of diseases, ie aging …
represents the primary risk factor in the pathogenesis of a variety of diseases, ie aging …
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic
M Majchrzak, M Poręba - Pharmacological Reports, 2022 - Springer
The unprecedented pandemic of SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2), which leads to COVID-19, is threatening global health. Over the last 2 years …
coronavirus 2), which leads to COVID-19, is threatening global health. Over the last 2 years …
[HTML][HTML] Matrix metalloproteinase/Fas ligand (MMP/FasL) interaction dynamics in COVID-19: An in silico study and neuroimmune perspective
Background The initiator of cytokine storm in Coronavirus disease (COVID-19) is still
unknown. We recently suggested a complex interaction of matrix metalloproteinases …
unknown. We recently suggested a complex interaction of matrix metalloproteinases …