When a molecule absorbs a photon of appropriate energy, a chain of photophysical events
ensues, such as internal conversion or vibrational relaxation (loss of energy in the absence …

Fast and non-invasive, diagnostic techniques based on fluorescence spectroscopy have the
potential to link the biochemical and morphologic properties of tissues to individual patient …

NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form,
NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced …

The altered metabolism of tumor cells confers a selective advantage for survival and
proliferation, and studies have shown that targeting such metabolic shifts may be a useful …

Background Mammographically dense breast tissue is one of the greatest risk factors for
develo** breast carcinoma. Despite the strong clinical correlation, breast density has not …

Time-correlated single photon counting (TCSPC) is based on the detection of single photons
of a periodic light signal, measurement of the detection time of the photons, and the build-up …

Biochemical estimation of NADH concentration is a useful method for monitoring cellular
metabolism, because the NADH/NAD+ reduction-oxidation pair is crucial for electron …

Rationale: Fibered confocal fluorescence microscopy (FCFM) is a new technique that
produces microscopic imaging of a living tissue through a 1-mm fiberoptic probe that can be …

Image sensors capable of capturing individual photons have made tremendous progress in
recent years. However, this technology faces a major limitation. Because they capture scene …

This paper reviews the recent developments in the field of biomedical optical imaging,
emphasizing technologies that have been moved from'bench top to bedside'. Important new …