Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …

Mass cytometry is attracting significant attention for enabling spatiotemporal high‐
throughput single‐cell analysis. As the first demonstration of the simultaneous detection of …

Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to
different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis …

Drug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive
oxygen species (ROS) are master regulators of cancer development that act through …

Chemoresistance represents the main obstacle to cancer treatment with both conventional
and targeted therapy. Beyond specific molecular alterations, which can lead to targeted …

Cancer metastasis and recurrence are obstacles to successful treatment of aggressive
cancer. To address this challenge, chemotherapy is indispensable as an essential part of …

Background Multidrug resistance (MDR) limits the beneficial outcomes of conventional
breast cancer chemotherapy. Ras-related nuclear protein (Ran-GTP) plays a key role in …