Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Impaired diabetic wound healing represents a devastating and rapidly growing clinical
problem associated with high morbidity, mortality, and recurrence rates. Engineering …

Hexanucleotide repeat expansions represent the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the mechanisms …

Oxidative phosphorylation is a source of energy production by which many cells satisfy their
energy requirements. Endogenous reactive oxygen species (ROS) are by-products of …

Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …

Reactive oxygen and nitrogen species damage cellular macromolecules including DNA.
Cells have a robust base excision repair pathway to deal with this damage in both nuclear …

Abstract Tyrosyl–DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are eukaryotic enzymes
that clean-up after aberrant topoisomerase activity. While TDP1 hydrolyzes phosphotyrosyl …

Background Cigarette smoke is the main risk factor of pulmonary emphysema development,
which is characterized by alveolar wall destruction. Mitochondria are important for alveolar …

Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type
2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) …