The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Cancer is one of the most concerning public health issues and breast cancer is one of the
most common cancers in the world. The immune cells within the tumor microenvironment …

Neoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in
patients with macroscopic stage III melanoma in the phase 1b OpACIN (NCT02437279) and …

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …

Background Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of
patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did …

Gliomas are the most aggressive primary intracranial malignancies with poor overall
survival. ITGA5 is one member of the integrin adhesion molecule family and is implicated in …

In the past decade, immune checkpoint inhibitors (ICI) have been approved for treatment of
genitourinary malignancies and have revolutionized the treatment landscape of these …

Objectives Transcriptomic-based subty**, consensus molecular subty** (CMS) and
colorectal cancer intrinsic subty** (CRIS) identify a patient subpopulation with …

Background The tumour stroma is associated with unfavourable prognosis in diverse solid
tumours, but its prognostic and predictive value in bladder cancer (BCa) is unclear. Methods …