Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which
connect proximal or distant cells and facilitate intercellular transfer. The identification of …

Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly
constitute a critical cell signaling network that has multiple functions. The tyrosine kinase …

More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

BACKGROUND: The possibility that μ opioid agonists can influence cancer recurrence is a
subject of recent interest. Epidemiologic studies suggested that there were differences in …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Identifying specific somatic mutations that drive tumor growth has transformed the treatment
of lung cancer. For example, cancers with sensitizing epidermal growth factor receptor …

Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor
tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical …