Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual
uncovering of substrate mechanical characteristics that can affect cell-matrix interactions …

Actin filaments assemble into diverse protrusive and contractile structures to provide force
for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

The shapes of eukaryotic cells and ultimately the organisms that they form are defined by
cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of …

It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by …

The development of biomaterials for drug delivery, tissue engineering and medical
diagnostics has traditionally been based on new chemistries. However, there is growing …

Cell alignment plays a critical role in various cell behaviors including cytoskeleton
reorganization, membrane protein relocation, nucleus gene expression, and ECM …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …

As materials technology and the field of biomedical engineering advances, the role of
cellular mechanisms, in particular adhesive interactions with implantable devices, becomes …

The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …