Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Fructose consumption is linked to the rising incidence of obesity and cancer, which are two
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …

Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and
others have found that a subset of patients experiences paradoxical rapid cancer …

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Activated T cells engage aerobic glycolysis and anabolic metabolism for growth,
proliferation, and effector functions. We propose that a glucose-poor tumor …

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …

Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein,
but its role in modulating macrophage-related inflammation during liver fibrosis has not been …