The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …

There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …

In this study, new co-amorphous drug systems were designed using a pharmacologically
relevant combination to improve the solubility and dissolution of indomethacin …

The objective of this study was to prepare a co-amorphous formulation of piroxicam (PIR), a
non-steroidal anti-inflammatory drug, and citric acid (CA), and evaluate its skin permeation …

Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …

In the recent years, coamorphous systems, containing an active pharmaceutical ingredient
(API) and a small molecule coformer have appeared as alternatives to the use of either …