Promising applications of tumor spheroids and organoids for personalized medicine
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
The increasing number of publications on the subject shows that nanomedicine is an
attractive field for investigations aiming to considerably improve anticancer chemotherapy …
attractive field for investigations aiming to considerably improve anticancer chemotherapy …
Axial pharmaceutical properties of liposome in cancer therapy: Recent advances and perspectives
Abstract Evaluation of axial properties including preparation, surface functionalization, and
pharmacokinetics for delivery of pharmacologically active molecules and genes lead to …
pharmacokinetics for delivery of pharmacologically active molecules and genes lead to …
Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors
Neurodegenerative diseases (NDs) and brain tumors are severe, disabling, and incurable
disorders that represent a critical problem regarding human suffering and the economic …
disorders that represent a critical problem regarding human suffering and the economic …
Improving anti-tumour efficacy of PEGylated liposomal doxorubicin by dual targeting of tumour cells and tumour endothelial cells using anti-p32 CGKRK peptide
The aim of this study was to surface-functionalize PEGylated liposomal doxorubicin (PLD)
using anti-p32 CGKRK peptide to evaluate its anti-angiogenic and anti-tumour activities …
using anti-p32 CGKRK peptide to evaluate its anti-angiogenic and anti-tumour activities …
Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models
Numerous strategies have been developed to treat cancer conventionally. Most importantly,
chemotherapy shows its huge promise as a better treatment modality over others …
chemotherapy shows its huge promise as a better treatment modality over others …
Ligand decorated biodegradable nanomedicine in the treatment of cancer
Cancer is one of the major global health problems, responsible for the second-highest
number of deaths. The genetic and epigenetic changes in the oncogenes or tumor …
number of deaths. The genetic and epigenetic changes in the oncogenes or tumor …
Methotrexate-based amphiphilic prodrug nanoaggregates for co-administration of multiple therapeutics and synergistic cancer therapy
The goal of nanomedicine is to seek strategies that are more efficient to address various
limitations and challenges faced by conventional medicines, including lack of target …
limitations and challenges faced by conventional medicines, including lack of target …
Mimicking Tumors: Toward More Predictive In Vitro Models for Peptide- and Protein-Conjugated Drugs
D van den Brand, LF Massuger, R Brock… - Bioconjugate …, 2017 - ACS Publications
Macromolecular drug candidates and nanoparticles are typically tested in 2D cancer cell
culture models, which are often directly followed by in vivo animal studies. The majority of …
culture models, which are often directly followed by in vivo animal studies. The majority of …
Control of liposomal penetration into three-dimensional multicellular tumor spheroids by modulating liposomal membrane rigidity
Effective penetration of drug-carrying nanoparticles into solid tumors is a major challenge in
cancer therapy. Exploration of the physicochemical properties of nanoparticles that affect …
cancer therapy. Exploration of the physicochemical properties of nanoparticles that affect …