Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by
parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is …

Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease
characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and …

Multiple system atrophy (MSA), corticobasal degeneration (CBD) and progressive
supranuclear palsy (PSP) are the most common atypical parkinsonisms. These adult-onset …

Prions are assemblies of misfolded prion protein that cause several fatal and transmissible
neurodegenerative diseases, with the most common phenotype in humans being sporadic …

Synaptic function is essential for cognition and loss of synapses is observed in
neurodegenerative tauopathies including Progressive Supranuclear Palsy (PSP) …

We conducted the largest PSP GWAS of the Iberian population to date (522 cases from 22
Spanish and Portuguese institutions). We independently replicated seven known PSP risk …

Astrocytes have multiple crucial roles, including maintaining brain homeostasis and synaptic
function, performing phagocytic clearance and responding to injury and repair. It has been …

Protein aggregates are a hallmark of neurodegenerative disease, yet the molecular
processes that control their appearance are still poorly understood. In particular, it is …

Abstract Frontotemporal Lobar Degeneration (FTLD) represents a spectrum of clinically,
genetically, and pathologically heterogeneous neurodegenerative disorders characterised …

Syntaxin-6, a SNARE protein involved in intracellular protein trafficking, is a proposed risk
factor for sporadic prion disease, progressive supranuclear palsy and Alzheimer's disease …