Autosomal-dominant Alzheimer's disease has provided significant understanding of the
pathophysiology of Alzheimer's disease. The present review summarizes clinical …

Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2
(PSEN2) genes cause autosomal dominant familial Alzheimer's disease (AD). PSEN1 and …

Familial Alzheimer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage
by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides …

Excitatory neurotransmitter dysfunction has been discussed to be involved in the
pathophysiology of Alzheimer's disease (AD). In the current study we investigated gene and …

Objective The sigma 1 receptor is considered to be involved in cognitive function. A
postmortem study reported that the sigma 1 receptors were reduced in the hippocampus in …

Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs.
Mostly, they act to stabilize microtubules and inhibit cell division. While not without side …

Early‐onset familial Alzheimer's disease (AD) caused by presenilin‐1 mutation E280A (PS1‐
E280A) presents wide clinical and neuropathological variabilities. We characterized …

In Alzheimer's disease (AD), Purkinje neurons in the cerebellum are spared, while, for
instance, pyramidal neurons in the hippocampus are neuropathologically affected. Several …

The clinical diagnosis of Alzheimer's disease (AD) is a probabilistic formulation that may lack
accuracy particularly at early stages of the dementing process. Abnormalities in amyloid …

We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer's disease (AD),
both in terms of the conservation of genes involved in AD and the regulatory responses of …