Objectives We reviewed the existing definitions of psychological frailty and provided a
comprehensive overview of the concept and associated measurements. Study Design and …

Many factors have contributed to rendering frailty an emerging, relevant, and very popular
concept. First, many pandemics that have affected humanity in history, including COVID-19 …

Cross-sectional studies have demonstrated strong associations between physical frailty and
depression. However, the evidence from prospective studies is limited. Here, we analyze …

We leveraged information from more than 1.2 million participants, including 97,383 cases, to
investigate the genetics of anxiety disorders across five continental groups. Through …

The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …

The incidence of frailty and cardiovascular disease (CVD) increases as the population ages.
There is a bidirectional relationship between frailty and CVD, and both conditions share …

Aims Bipolar disorders are clinically complex, chronic and recurrent disorders. Few
treatment options are effective across hypomanic, manic, depressive and mixed states and …

High-quality diets have been increasingly acknowledged as a promising candidate to
counter the growing prevalence of mental health disorders. This study aims to investigate …

BackgroundThe association of COVID-19 with death in people with severe mental illness
(SMI), and associations with multimorbidity and ethnicity, are unclear. AimsTo determine all …

Objectives Although observational studies have reported the association between frailty and
mental disorders, the causality remains unclear. We aimed to evaluate the bidirectional …