In vivo aspects of protein folding and quality control
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
Molecular chaperone functions in protein folding and proteostasis
The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
Intracellular targeting mechanisms by antimicrobial peptides
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …
defenses against potential harmful encounters in their surroundings. AMPs are short …
Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones
MP Mayer, LM Gierasch - Journal of Biological Chemistry, 2019 - ASBMB
Hsp70 chaperones are central hubs of the protein quality control network and collaborate
with co-chaperones having a J-domain (an∼ 70-residue–long helical hairpin with a flexible …
with co-chaperones having a J-domain (an∼ 70-residue–long helical hairpin with a flexible …
The GroEL–GroES chaperonin machine: a nano-cage for protein folding
The bacterial chaperonin GroEL and its cofactor GroES constitute the paradigmatic
molecular machine of protein folding. GroEL is a large double-ring cylinder with ATPase …
molecular machine of protein folding. GroEL is a large double-ring cylinder with ATPase …
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
Chaperones are abundant cellular proteins that promote the folding and function of their
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
Recent advances in understanding catalysis of protein folding by molecular chaperones
Molecular chaperones are highly conserved proteins that promote proper folding of other
proteins in vivo. Diverse chaperone systems assist de novo protein folding and trafficking …
proteins in vivo. Diverse chaperone systems assist de novo protein folding and trafficking …
Functional modules of the proteostasis network
Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis)
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
Protein folding and mechanisms of proteostasis
JF Díaz-Villanueva, R Díaz-Molina… - International journal of …, 2015 - mdpi.com
Highly sophisticated mechanisms that modulate protein structure and function, which involve
synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in …
synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in …
How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions
EM Clerico, JM Tilitsky, W Meng… - Journal of molecular …, 2015 - Elsevier
Hsp70 molecular chaperones are implicated in a wide variety of cellular processes,
including protein biogenesis, protection of the proteome from stress, recovery of proteins …
including protein biogenesis, protection of the proteome from stress, recovery of proteins …