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COVID-19 and cellular senescence
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
[HTML][HTML] Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
[HTML][HTML] Skin aging, cellular senescence and natural polyphenols
E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …
impacting its morphology and function. Senescent cells have been found to accumulate with …
Ketogenic diet induces p53-dependent cellular senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of
ketones. While KDs improve certain health conditions and are popular for weight loss …
ketones. While KDs improve certain health conditions and are popular for weight loss …
Cellular senescence: Neither irreversible nor reversible
Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …
Hallmarks of cellular senescence
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …
remodeling during development and after injury, but can also contribute to the decline of the …
Mechanisms and functions of cellular senescence
N Herranz, J Gil - The Journal of clinical investigation, 2018 - jci.org
Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
The dynamic nature of senescence in cancer
Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …
development, wound healing, age-related decline in organ functions and cancer. Here, we …