Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …

The adenovirus, an 80–100 nm, nonenveloped, icosa-hedral capsid, double-stranded DNA
virus, is a wellknown cause of respiratory tract infections (Ginsberg, 1984). Adenovirus …

Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Background—Recombinant human vascular endothelial growth factor protein (rhVEGF)
stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials …

Cardiovascular diseases remain a large global health problem. Although several
conventional small-molecule treatments are available for common cardiovascular problems …

Background—Several clinical studies are evaluating the therapeutic potential of delivery of
various progenitor cells for treatment of injured hearts. However, the actual fate of delivered …

Background—Single-bolus intracoronary administration of fibroblast growth factor-2 (FGF2)
improved symptoms and myocardial function in a phase I, open-label trial in patients with …

Background—Catheter-based intracoronary vascular endothelial growth factor (VEGF) gene
transfer is a potential treatment for coronary heart disease. However, only limited data are …

Background—“Therapeutic angiogenesis” seeks to improve perfusion by the growth of new
blood vessels. The Regional Angiogenesis with Vascular Endothelial growth factor (RAVE) …