Viral vector platforms within the gene therapy landscape
Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …
transitions. It has seen great strides in combating human disease, has given hope to patients …
[HTML][HTML] Vascular endothelial growth factor (VEGF) delivery approaches in regenerative medicine
The utilization of growth factors in the process of tissue regeneration has garnered
significant interest and has been the subject of extensive research. However, despite the …
significant interest and has been the subject of extensive research. However, despite the …
Vascular endothelial growth factor and angiogenesis
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …
Adenovirus: The First Effective In Vivo Gene Delivery Vector
RG Crystal - Human gene therapy, 2014 - liebertpub.com
The adenovirus, an 80–100 nm, nonenveloped, icosa-hedral capsid, double-stranded DNA
virus, is a wellknown cause of respiratory tract infections (Ginsberg, 1984). Adenovirus …
virus, is a wellknown cause of respiratory tract infections (Ginsberg, 1984). Adenovirus …
The role of vascular endothelial growth factor in wound healing
BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …
The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis
Background—Recombinant human vascular endothelial growth factor protein (rhVEGF)
stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials …
stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials …
Cardiovascular gene therapy: past, present, and future
Cardiovascular diseases remain a large global health problem. Although several
conventional small-molecule treatments are available for common cardiovascular problems …
conventional small-molecule treatments are available for common cardiovascular problems …
Gene therapy for the heart lessons learned and future perspectives
While clinical gene therapy celebrates its first successes, with several products already
approved for clinical use and several hundreds in the final stages of the clinical approval …
approved for clinical use and several hundreds in the final stages of the clinical approval …
Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
D Hou, EAS Youssef, TJ Brinton, P Zhang, P Rogers… - Circulation, 2005 - ahajournals.org
Background—Several clinical studies are evaluating the therapeutic potential of delivery of
various progenitor cells for treatment of injured hearts. However, the actual fate of delivered …
various progenitor cells for treatment of injured hearts. However, the actual fate of delivered …