Horizontal transfer of antibiotic resistance genes in clinical environments

NA Lerminiaux, ADS Cameron - Canadian journal of …, 2019 - cdnsciencepub.com
A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Convergence of Biofilm Formation and Antibiotic Resistance in Acinetobacter baumannii Infection

S Roy, G Chowdhury, AK Mukhopadhyay… - Frontiers in …, 2022 - frontiersin.org
Acinetobacter baumannii (A. baumannii) is a leading cause of nosocomial infections as this
pathogen has certain attributes that facilitate the subversion of natural defenses of the …

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment

Z Lin, T Yuan, L Zhou, S Cheng, X Qu, P Lu… - … geochemistry and health, 2021 - Springer
Antibiotic resistance is a great concern, which leads to global public health risks and
ecological and environmental risks. The presence of antibiotic-resistant genes and antibiotic …

Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace

MS Ramirez, RA Bonomo, ME Tolmasky - Biomolecules, 2020 - mdpi.com
Acinetobacter baumannii is a common cause of serious nosocomial infections. Although
community-acquired infections are observed, the vast majority occur in people with …

Acinetobacter species as model microorganisms in environmental microbiology: current state and perspectives

J Jung, W Park - Applied microbiology and biotechnology, 2015 - Springer
Acinetobacter occupies an important position in nature because of its ubiquitous presence in
diverse environments such as soils, fresh water, oceans, sediments, and contaminated sites …

Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation

N Vesel, M Blokesch - Journal of bacteriology, 2021 - Am Soc Microbiol
Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-
resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its …

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens

E Pursey, T Dimitriu, FL Paganelli… - … of the Royal …, 2022 - royalsocietypublishing.org
The acquisition of antibiotic resistance (ABR) genes via horizontal gene transfer (HGT) is a
key driver of the rise in multidrug resistance amongst bacterial pathogens. Bacterial defence …

Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands by natural transformation in pathogenic Acinetobacter

AS Godeux, E Svedholm, S Barreto, A Potron… - MBio, 2022 - Am Soc Microbiol
Acinetobacter baumannii infection poses a major health threat, with recurrent treatment
failure due to antibiotic resistance, notably to carbapenems. While genomic analyses of …