Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection
W Chen, Y Shao, X Peng, B Liang, J Xu… - Frontiers in …, 2022 - frontiersin.org
Main protease (Mpro) is a superior target for anti-SARS-COV-2 drugs. PF-07304814 is a
phosphate ester prodrug of PF-00835231 that is rapidly metabolized into the active …
phosphate ester prodrug of PF-00835231 that is rapidly metabolized into the active …
Marine Alga Ulva fasciata-Derived Molecules for the Potential Treatment of SARS-CoV-2: An In Silico Approach
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This in silico study aimed to
elucidate therapeutic efficacies against SARS-CoV-2 of phyco-compounds from the …
elucidate therapeutic efficacies against SARS-CoV-2 of phyco-compounds from the …
Antimicrobial Activity of Rhenium Di- and Tricarbonyl Diimine Complexes: Insights on Membrane-Bound S. aureus Protein Binding
Antimicrobial resistance is one of the major human health threats, with significant impacts on
the global economy. Antibiotics are becoming increasingly ineffective as drug-resistance …
the global economy. Antibiotics are becoming increasingly ineffective as drug-resistance …
A multilevel approach for screening natural compounds as an antiviral agent for COVID-19
The COVID-19 has a worldwide spread, which has prompted concerted efforts to find
successful drug treatments. Drug design focused on finding antiviral therapeutic agents from …
successful drug treatments. Drug design focused on finding antiviral therapeutic agents from …
Inhibition ability of natural compounds on receptor-binding domain of SARS-CoV2: an in silico approach
The lack of medication to treat COVID-19 is still an obstacle that needs to be addressed by
all possible scientific approaches. It is essential to design newer drugs with varied …
all possible scientific approaches. It is essential to design newer drugs with varied …
Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: potential pH-dependent inhibition explored through computer-aided …
LD Goyzueta-Mamani… - Frontiers in …, 2024 - frontiersin.org
Visceral Leishmaniasis (VL) is a serious public health issue, documented in more than
ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of …
ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of …
MD simulations indicate Omicron P132H of SARS-CoV-2 Mpro is a potential allosteric mutant involved in modulating the dynamics of catalytic site entry loop
The SARS-CoV-2 main protease M pro, essential for viral replication is an important drug
target. It plays a critical role in processing viral polyproteins necessary for viral replication …
target. It plays a critical role in processing viral polyproteins necessary for viral replication …
[HTML][HTML] Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy
LD Goyzueta-Mamani, DP Lage… - …, 2025 - pmc.ncbi.nlm.nih.gov
Leishmaniasis, a neglected tropical disease caused by Leishmania species, presents
serious public health challenges due to limited treatment options, toxicity, high costs, and …
serious public health challenges due to limited treatment options, toxicity, high costs, and …
Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: pH-dependent inhibition explored through computer-aided drug design
Visceral Leishmaniasis (VL) is a serious public health issue, documented in more than
ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of …
ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of …
Effect of pH on stability of dimer structure of the main protease of coronavirus-2
The viral main protease (M pro) from a novel severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) is a key enzyme essential for viral replication and has become an attractive …
2 (SARS-CoV-2) is a key enzyme essential for viral replication and has become an attractive …