Protein ubiquitylation is a post‐translational modification that controls all aspects of
eukaryotic cell functionality, and its defective regulation is manifested in various human …

The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not
known. In contrast, mechanistic understanding of other brain disorders including …

The family of potassium channel tetramerizationdomain (KCTD) proteins consists of 26
members with mostly unknown functions. The name of the protein family is due to the …

Neuronal ceroid lipofuscinoses (NCL) comprise a group of inherited lysosomal disorders
with variable age of onset, characterized by lysosomal accumulation of autofluorescent …

The E3 ligases recruit substrate proteins for targeted ubiquitylation. Recent insights into the
mechanisms of ubiquitylation demonstrate that E3 ligases can possess active regulatory …

Members of the potassium channel tetramerization domain (KCTD) family are soluble non-
channel proteins that commonly function as Cullin3 (Cul3)-dependent E3 ligases. Solution …

Neuronal ceroid lipofuscinosis (NCL) is a genetically heterogeneous group of lysosomal
diseases that collectively compose the most common Mendelian form of childhood-onset …

Numerous mutations in the Plasmodium falciparum Kelch13 (K13) protein confer resistance
to artemisinin derivatives, the current front-line antimalarial drugs. K13 is an essential …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

The KCTD family includes tetramerization (T1) domain containing proteins with diverse
biological effects. We identified a novel member of the KCTD family, BTBD10. A …