Tumor glycolysis, an essential sweet tooth of tumor cells

S Paul, S Ghosh, S Kumar - Seminars in cancer biology, 2022‏ - Elsevier
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Cisplatin in cancer treatment

AMP Romani - Biochemical pharmacology, 2022‏ - Elsevier
Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …

METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy

Y Sun, W Shen, S Hu, Q Lyu, Q Wang, T Wei… - Journal of Experimental …, 2023‏ - Springer
Background Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer.
Although most patients are initially sensitive to first-line combination chemotherapy with …

Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets

R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023‏ - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

D Xu, Y Li, S Yin, F Huang - Chemical Society Reviews, 2024‏ - pubs.rsc.org
Owing to their capacity for dynamically linking two or more functional molecules,
supramolecular coordination complexes (SCCs), exemplified by two-dimensional (2D) …

Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy

PB Tchounwou, S Dasari, FK Noubissi… - Journal of …, 2021‏ - Taylor & Francis
Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022‏ - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment

YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021‏ - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

Reversal of cisplatin chemotherapy resistance by glutathione-resistant copper-based nanomedicine via cuproptosis

Y Lu, Q Pan, W Gao, Y Pu, B He - Journal of Materials Chemistry B, 2022‏ - pubs.rsc.org
Platinum-based chemotherapy is widely used to treat various cancers. However, exogenous
platinum is likely to cause severe side effects and drug resistance induced by upregulated …

Cisplatin: The first metal based anticancer drug

S Ghosh - Bioorganic chemistry, 2019‏ - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …