Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium
that produces porcine pleuropneumonia. This highly contagious disease produces high …

Akkermansia muciniphila has received great attention because of its beneficial roles in gut
health by regulating gut immunity, promoting intestinal epithelial development, and …

Curli are extracellular functional amyloids that are assembled by enteric bacteria during
biofilm formation and host colonization. An efficient secretion system and chaperone …

Production of recombinant proteins at high yields in Escherichia coli requires extensive
optimization of expression conditions. Production is further complicated for proteins that …

Purpose Salmonellosis in poultry is a serious economic burden. A major concern is the
public health hazard caused by consumption of Salmonella-contaminated poultry products …

Infections by Gram-negative pathogens represent a major health care issue of growing
concern due to a striking lack of novel antibacterial agents over the course of the last …

Abstract L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme
to treat acute lymphoblastic leukemia. However, the side effects associated with the …

Light chain (LC) amyloidosis (AL amyloidosis) appears to be caused by the misfolding, or
misfolding and aggregation of an antibody LC or fragment thereof and is fatal if untreated …

Females have an overall advantage over males in resisting Gram-negative bacteremias,
thus hinting at sexual dimorphism of immunity during infections. Here, through intravital …

Summary Type-1 secretion systems (T1SSs) represent a widespread mode of protein
secretion across the cell envelope in Gram-negative bacteria. The T1SS is composed of an …