Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic

S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg… - Circulation, 2021 - ahajournals.org
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …

Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine

L Chen, J Qu, Q Mei, X Chen, Y Fang, L Chen… - Stem Cell Research & …, 2021 - Springer
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in
regenerative medicine. MenSC has received increasing attention owing to its impressive …

Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF‐1α‐mediated promotion of angiogenesis in a rat model of …

Y Zhang, Z Hao, P Wang, Y **a, J Wu, D **a… - Cell …, 2019 - Wiley Online Library
Objectives Exosomes, as important players in intercellular communication due to their ability
to transfer certain molecules to target cells, are believed to take similar effects in promoting …

Co-delivery of bioengineered exosomes and oxygen for treating critical limb ischemia in diabetic mice

T Zhong, N Gao, Y Guan, Z Liu, J Guan - Acs Nano, 2023 - ACS Publications
Diabetic patients with critical limb ischemia face a high rate of limb amputation.
Regeneration of the vasculature and skeletal muscles can salvage diseased limbs. Therapy …

Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after myocardial …

D Shen, Z He - Annals of translational medicine, 2021 - pmc.ncbi.nlm.nih.gov
Background Myocardial ischemia-reperfusion injury is a type of myocardial ischemia that
has a significant impact on patients' health. We aimed to explore the protective effect of …

Injectable hyaluronic acid hydrogel loaded with functionalized human mesenchymal stem cell aggregates for repairing infarcted myocardium

Y Lyu, J **e, Y Liu, M **ao, Y Li, J Yang… - ACS biomaterials …, 2020 - ACS Publications
Conventional strategies of stem cell injection in treating myocardial infarction (MI) remain a
challenge because of low retention rate and insufficient secretion of exogenous cytokines for …

Exosomes for angiogenesis induction in ischemic disorders

K Moeinabadi‐Bidgoli, M Rezaee… - Journal of cellular …, 2023 - Wiley Online Library
Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the
current therapeutic approaches have improved life expectancy and quality of life, they are …

Recent advances in extracellular vesicles as drug delivery systems and their potential in precision medicine

B de Jong, ER Barros, JGJ Hoenderop, JP Rigalli - Pharmaceutics, 2020 - mdpi.com
Extracellular vesicles (EVs) are membrane-bilayered nanoparticles released by most cell
types. Recently, an enormous number of studies have been published on the potential of …

HuMSC-EV induce monocyte/macrophage mobilization to orchestrate neovascularization in wound healing process following radiation injury

C Loinard, A Ribault, B Lhomme, M Benderitter… - Cell Death …, 2023 - nature.com
This study aims to investigate the mechanisms of human mesenchymal stem cell-derived
extracellular vesicles (HuMSC-EV)-induced proangiogenic paracrine effects after radiation …

Modular bioorthogonal lipid nanoparticle modification platforms for cardiac homing

R Cruz-Samperio, CL Hicks, A Scott… - Journal of the …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) are becoming widely adopted as vectors for the delivery of
therapeutic payloads but generally lack intrinsic tissue-homing properties. These …